Author

Sandra Brosda

The University of QueenslandORCID 0000-0002-0867-6166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:large language model· 1

Frequent Co-Authors

Andrew P. BarbouriD· 2 shared Anna TrigosiD· 1 shared Caroline Louise CooperiD· 1 shared Clemence J. BelleiD· 1 shared Cuong Phu Duong· 1 shared David S Liu· 1 shared Ebtihal H MustafaiD· 1 shared Eric P. KusnadiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Andrew P. BarbourORCID

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2 papers

Recent·Most cited

SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogramming

Julia V. Milne, Kameng Wu, Eric P. Kusnadi, Sandra Brosda, Kenji Mark Fujihara, Ebtihal H Mustafa, Sasha Witts, Katherine Papastratos, Maree Pechlivanis, Anna Trigos, Metta K. Jana, Paul J. McMillan, Thomas Daniel Jackson, Niko Thio, Yuzhou Feng, , Nicholas James Clemons

This study shows SMAD4 loss reprograms translation to induce chromosomal instability, driving tumourigenesis, and identifies CDK11B-p58 as a key mediator.

bioRxiv · Mar 25, 2026 · PreprintCancer Biology

Agent SPI-WSI: In context learning for computationally spatial pathwayinferring on whole slide histopathology images conditioned on bulk RNAsequencing using pathologist in the loop.

Rajat Vashistha, Sandra Brosda, Clemence J. Belle, Lauren G. Aoude, Nicola Waddell, Soumen Ghosh, Caroline Louise Cooper, Andrew P. Barbour, Viktor Vegh

The paper introduces an AI agent that localizes bulk RNA-seq pathway activity in histopathology images using pathologist feedback and large language models.

bioRxiv · Oct 16, 2025 · PreprintBioinformatics