Author

Niko Thio

The University of MelbourneORCID 0000-0002-3089-0871Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Ebtihal H MustafaiD· 2 shared Julia V. MilneiD· 2 shared Kameng Wu· 2 shared Katherine Papastratos· 2 shared Maree Pechlivanis· 2 shared Nicholas James ClemonsiD· 2 shared Sasha WittsiD· 2 shared Wayne Allen PhillipsiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Ebtihal H MustafaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Mapping Functional Tumor Suppressor Networks in Esophageal Adenocarcinoma Using In Vivo CRISPR Screening and Perturb-sequencing

Ebtihal H Mustafa, Katherine Papastratos, Kameng Wu, Niko Thio, Julia V. Milne, Natasha Mitchell, Sasha Witts, Maree Pechlivanis, Bonnie Wong, Nicola Waddell, Wayne Allen Phillips, Nicholas James Clemons

The paper identifies tumor suppressors and their functional roles in esophageal adenocarcinoma progression using CRISPR screening and Perturb-seq.

bioRxiv · Jul 21, 2026 · PreprintCancer Biology

SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogramming

Julia V. Milne, Kameng Wu, Eric P. Kusnadi, Sandra Brosda, Kenji Mark Fujihara, Ebtihal H Mustafa, Sasha Witts, Katherine Papastratos, Maree Pechlivanis, Anna Trigos, Metta K. Jana, Paul J. McMillan, Thomas Daniel Jackson, Niko Thio, Yuzhou Feng, , Nicholas James Clemons

This study shows SMAD4 loss reprograms translation to induce chromosomal instability, driving tumourigenesis, and identifies CDK11B-p58 as a key mediator.

bioRxiv · Mar 25, 2026 · PreprintCancer Biology

DNA sequencing and gene-expression profiling assists in making a tissue of origin diagnosis in cancer of unknown primary

Atara Posner, Owen W.J. Prall, Tharani Sivakumaran, Dariush Etemadamoghadam, Niko Thio, Andrew Pattison, Shiva Balachander, Krista Fisher, Samantha Webb, Colin S. Wood, Anna DeFazio, Nicholas R. C. Wilcken, Bo Gao, Christos Stelios Karapetis, Madhu Sudan Singh, , Richard W. Tothill

This study combines DNA sequencing and gene-expression profiling with clinical data to improve diagnosis of cancer of unknown primary (CUP), identifying potential tissue origins in over a third of cases.

medRxiv · Jun 24, 2022 · PreprintGenetic & Genomic Medicine