Author

Yuzhou Feng

Peter MacCallum Cancer CentreORCID 0000-0002-2955-4053Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Alicia OshlackiD· 1 shared Andrew P. BarbouriD· 1 shared Anna TrigosiD· 1 shared Cuong Phu Duong· 1 shared Dane VassiliadisiD· 1 shared David S Liu· 1 shared Ebtihal H MustafaiD· 1 shared Eric P. KusnadiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioinformatics

Alicia OshlackORCID

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2 papers

Recent·Most cited

SMAD4 loss drives chromosomal instability during tumourigenesis via translational reprogramming

Julia V. Milne, Kameng Wu, Eric P. Kusnadi, Sandra Brosda, Kenji Mark Fujihara, Ebtihal H Mustafa, Sasha Witts, Katherine Papastratos, Maree Pechlivanis, Anna Trigos, Metta K. Jana, Paul J. McMillan, Thomas Daniel Jackson, Niko Thio, Yuzhou Feng, , Nicholas James Clemons

This study shows SMAD4 loss reprograms translation to induce chromosomal instability, driving tumourigenesis, and identifies CDK11B-p58 as a key mediator.

bioRxiv · Mar 25, 2026 · PreprintCancer Biology

Benchmarking single-cell hashtag oligo demultiplexing methods

George Howitt, Yuzhou Feng, Lucas E. Tobar, Dane Vassiliadis, Peter F. Hickey, Mark A. Dawson, Sarath Ranganathan, Shivanthan Shanthikumar, Melanie R. Neeland, Jovana Maksimovic, Alicia Oshlack

This study benchmarks seven HTO demultiplexing tools using datasets with genetic variant-based ground truth, finding similar performance on high-quality data but poor performance on lower quality data for bimodal distribution methods.

NAR Genomics and Bioinformatics · Sep 19, 2023Peer-reviewedBioinformatics