The Effect of Celecoxib and muMab911 on Strain Adaptive Bone Remodeling and Fracture Repair in Female Mice: Implications for Rapidly Progressive Osteoarthritis
Nicholas J. Ruggiero, Alexandra Ciuciu, Ashkan Sedigh, Ibtesam Rajpar, David Shelton, Patrice C. Bélanger, Kathryn E. Gropp, John A. Collins, Theresa A. Freeman, Ryan E. Tomlinson
This study examines the effects of celecoxib and muMab911 on bone remodeling and fracture repair in mice, finding they suppress NGF expression and load-induced bone formation, potentially contributing to rapid osteoarthritis progression.
Bone · May 23, 2025Peer-reviewedBioengineering