Author

John A. Collins

Thomas Jefferson University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Assay:ATAC-seq· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Makarand V. RisbudiD· 3 shared Bahiyah WatsoniD· 2 shared Mallory TociiD· 2 shared Olivia K. OttoneiD· 2 shared Pranay L. RamtekeiD· 2 shared Qinglin Wu· 2 shared Ramkrishna MitraiD· 2 shared Ruteja A. BarveiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

Makarand V. RisbudORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

Pranay L. Ramteke, Bahiyah Watson, Sanjana Jagannath, Sarah Elizabeth Bell, Mallory Toci, Olivia K. Ottone, Qinglin Wu, Oliver Abinader, Ramkrishna Mitra, John A. Collins, Ruteja A. Barve, Makarand V. Risbud

This study shows that activating SIRT6 with MDL-800 improves intervertebral disc health in aged mice by enhancing autophagy, reducing senescence, and improving matrix quality.

bioRxiv · Mar 5, 2026 · PreprintBiochemistry

The Effect of Celecoxib and muMab911 on Strain Adaptive Bone Remodeling and Fracture Repair in Female Mice: Implications for Rapidly Progressive Osteoarthritis

Nicholas J. Ruggiero, Alexandra Ciuciu, Ashkan Sedigh, Ibtesam Rajpar, David Shelton, Patrice C. Bélanger, Kathryn E. Gropp, John A. Collins, Theresa A. Freeman, Ryan E. Tomlinson

This study examines the effects of celecoxib and muMab911 on bone remodeling and fracture repair in mice, finding they suppress NGF expression and load-induced bone formation, potentially contributing to rapid osteoarthritis progression.

Bone · May 23, 2025Peer-reviewedBioengineering

Oral citrate supplementation mitigates age-associated pathological intervertebral disc calcification in LG/J mice

Olivia K. Ottone, Jorge J. Mundo, Boahen N. Kwakye, Amber Slaweski, John A. Collins, Qinglin Wu, Margery A. Connelly, Fatemeh Niaziorimi, Koen van de Wetering, Makarand V. Risbud

This study shows oral K3Citrate reduces disc calcification in LG/J mice without affecting bone structure or locomotion, suggesting Ca2+ chelation as a potential mechanism.

Aging Cell · Feb 11, 2025Peer-reviewedCell Biology

SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status

Pranay L. Ramteke, Bahiyah Watson, Mallory Toci, Victoria A. Tran, Shira N. Johnston, Maria Tsingas, Ruteja A. Barve, Ramkrishna Mitra, Richard F. Loeser, John A. Collins, Makarand V. Risbud

This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.

bioRxiv · Sep 9, 2024 · PreprintMolecular Biology