Author

David Sparkman-Yager

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

James M. CarothersiD· 2 shared Aria WallsiD· 1 shared Cassandra R. BurkeiD· 1 shared Cholpisit KiattiseweeiD· 1 shared Héctor García MartíniD· 1 shared Ian FaulkneriD· 1 shared Jason T. FontanaiD· 1 shared Jesse G. ZalataniD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSynthetic Biology

James M. CarothersORCID

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2 papers

Recent·Most cited

Guide RNA structure design enables combinatorial CRISPRa programs for biosynthetic profiling

Jason T. Fontana, David Sparkman-Yager, Ian Faulkner, Ryan A. L. Cardiff, Cholpisit Kiattisewee, Aria Walls, Tommy G. Primo, Patrick C. Kinnunen, Héctor García Martín, Jesse G. Zalatan, James M. Carothers

The paper designs guide RNA structures for CRISPRa to optimize multi-gene expression in bacterial metabolic pathways, achieving higher product titers and identifying pathway bottlenecks.

Nature Communications · Jul 27, 2024Peer-reviewedSynthetic Biology

Multi-state design of kinetically-controlled RNA aptamer ribosensors

Cassandra R. Burke, David Sparkman-Yager, James M. Carothers

This paper designs and tests kinetically-controlled RNA aptamer ribosensors for improved ligand sensitivity and selectivity in microbial cultures.

bioRxiv · Nov 3, 2017 · PreprintSynthetic Biology