Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction
Matías Ciancaglini, Robin Avanthay, Anna‐Friederike Marx, Tiago Abreu-Mota, Davide Finozzi, Jonas Fixemer, Florian M. Geier, Dominik Bürri, Ingrid Wagner, Ilena Vincenti, Mario Kreuzfeldt, Doron Merkler, Gert Zimmer, Daniel D. Pinschewer
This paper re-engineers a cytolytic viral vector to be non-cytolytic, enhancing CD8 T cell immunity through reinforced type I IFN signaling.
Molecular Therapy — Nucleic Acids · Feb 3, 2026Peer-reviewedImmunology