Author

de Vries-Bouwstra Jk

Leiden University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Albert J. R. HeckiD· 1 shared Bart EvertsiD· 1 shared Corrie M. WorteliD· 1 shared Cynthia M. FehresiD· 1 shared Danique M.H. van RijswijckiD· 1 shared E. W. Nivine LevarhtiD· 1 shared Hans Ulrich SchereriD· 1 shared Marjolein J.A.L. WetzelsiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Albert J. R. HeckORCID

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1 paper

Recent·Most cited

Enhanced recognition of topoisomerase 1 upon DNA binding by a subset of anti-topoisomerase 1 autoantibodies in systemic sclerosis

Sam Neppelenbroek, Corrie M. Wortel, Danique M.H. van Rijswijck, Marjolein J.A.L. Wetzels, Robbert Q. Kim, Nikki M. Loof, Martina Erbì, E. W. Nivine Levarht, Bart Everts, Albert J. R. Heck, de Vries-Bouwstra Jk, Cynthia M. Fehres, René E.M. Toes, Hans Ulrich Scherer

This study shows that some anti-topoisomerase 1 autoantibodies (ATAs) in systemic sclerosis (SSc) bind more strongly to TOP1-DNA cleavage complexes, correlating with disease severity and immune activation.

Annals of the Rheumatic Diseases · Apr 12, 2026Peer-reviewedImmunology