ImmunologyAnnals of the Rheumatic DiseasesPeer-reviewed
Enhanced recognition of topoisomerase 1 upon DNA binding by a subset of anti-topoisomerase 1 autoantibodies in systemic sclerosis
Sam Neppelenbroek, Corrie M. Wortel, Danique M.H. van Rijswijck…·Hans Ulrich Scherer
This study shows that some anti-topoisomerase 1 autoantibodies (ATAs) in systemic sclerosis (SSc) bind more strongly to TOP1-DNA cleavage complexes, correlating with disease severity and immune activation.
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