Clonal CD8 T cells in the leptomeninges are locally controlled and influence microglia in human neurodegeneration
Ryan Hobson, Samuel H. S. Levy, Chitra Mohinder Singh Singal, Delaney Flaherty, Harrison Xiao, Benjamin Ciener, Hasini Reddy, Nick Zabinyakov, Christine Y. Kim, Andrew F. Teich, Neil A. Shneider, Elizabeth M. Bradshaw, Wassim Elyaman
The paper identifies clonal CD8 T cell activation in human meninges and their regulatory role in controlling neuroinflammation through interactions with natural killer cells.
Nature Immunology · Jan 27, 2026Peer-reviewedNeuroscience