Prabesh Bhattarai

This study shows that chronic FMNL2 overexpression in zebrafish causes brain histological changes and altered exploratory behavior similar to those seen after acute Aβ42 exposure.

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

This study investigates the evolutionary origins of Cajal-Retzius cells across vertebrates, finding they are conserved but gained specific transcriptomic features in amniotes.

This study identifies ABCA7-dependent neuropeptide Y signaling as a resilience mechanism critical for synaptic integrity and its disruption as a risk factor for Alzheimer's disease.

The paper identifies rare FN1 variants that protect APOEε4 carriers from Alzheimer's disease by modulating extracellular matrix deposition and gliosis.

The paper identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease by characterizing their effects on human microglial subtypes in vitro and in a zebrafish model.

The paper shows that Ngfr promotes neurogenesis and reduces amyloid pathology in AD mouse models by suppressing Lcn2/Slc22a17 signaling.

The paper uses single-cell transcriptomics to analyze how Amyloid-beta42 and Interleukin-4 affect neural stem/progenitor cell plasticity in adult zebrafish brain, identifying gene expression changes and cell-cell communication alterations.

This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.

This paper introduces a 3D hydrogel culture system to model human neural stem cell plasticity, neurogenesis, and neurodegeneration, showing improved neuronal maturation and disease modeling.