Wassim Elyaman

The paper identifies clonal CD8 T cell activation in human meninges and their regulatory role in controlling neuroinflammation through interactions with natural killer cells.

This study shows that loss of nuclear TDP-43 in microglia-like cells disrupts lipid metabolism, leading to increased lipid droplets, phagocytosis, and inflammation, which can be mitigated by DGAT inhibitors.

The paper identifies microglia subsets in ALS brain and spinal cord, finding an undifferentiated phenotype and enrichment of interferon response microglia in aggressive cases.

This study identifies CD45 as a sialic acid-dependent binding partner of CD33, showing that their interaction contributes to Alzheimer's disease susceptibility through impaired microglial function.

The paper computes polygenic risk scores for various disorders and correlates them with T cell gene expression in Alzheimer's patients and controls, identifying gene pathways related to T cell signaling and activation.

The paper investigates how Th17 cytokines influence microglial and blood-brain barrier responses during post-infectious encephalitis using single-cell RNA sequencing and spatial transcriptomics.