The 9p21.3 Coronary Artery Disease Risk Locus Modulates Vascular Cell-State Transitions via Enhancer-Driven Regulation of MTAP
Timothy N. Audam, Benjamin Schmandt, Yi Huang, Young Beum Cho, Mayank Murali, Rama Kaalia, Saaket Agrawal, Jinping Liu, Hongjie Shi, Zhou Yuan, Dengwei Cao, Lan Jiang, Yun Li, Jichen Wen, Zhao Hongqiang, , Melina Claussnitzer
This study identifies 12 enhancers in the 9p21.3 CAD risk locus that regulate MTAP, modulating vascular cell-state transitions and CAD risk through stress-responsive mechanisms.
bioRxiv · Nov 18, 2025 · PreprintGenomics