Protein CoAlation on TXNRD2 regulates mitochondrial thioredoxin system to protect against ferroptosis
Chao‐Chieh Lin, Yi-Tzu Lin, Ssu-Yu Chen, Yasaman Setayeshpour, Yubin Chen, Denise E Dunn, Erik J. Soderblom, Guo-Fang Zhang, Valeriy V Filonenko, Suh Young Jeong, Scott Floyd, Susan J. Hayflick, Ivan T. Gout, Jen‐Tsan Chi
This study identifies CoA-mediated post-translational modification of TXNRD2 as a novel mechanism regulating the mitochondrial thioredoxin system to protect against ferroptosis.
bioRxiv · May 16, 2024 · PreprintCell Biology