UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism
Phong Nguyen, Zheng Wu, Dohun Kim, Tamaratare Ogu, Siyu Yin, Varun Sondhi, Feng Cai, Trevor S. Tippetts, Annie Jen, Evgenia Shishkova, Ling Cai, Dennis Dumesnil, Margaret B. Cervantes, Hongli Chen, Prashant Mishra, , Ralph J. DeBerardinis
This study identifies UFMylation of PDH as a regulator of mitochondrial metabolism, showing it enhances pyruvate oxidation and TCA cycle activity.
bioRxiv · Mar 18, 2026 · PreprintBiochemistry