Zheng Wu

Metabolic landscape of inborn errors of metabolism

This study uses metabolomics to analyze 474 subjects with inborn errors of metabolism, identifying genotype-specific metabolic alterations and providing diagnostic tools and a database of metabolomic features.

UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism

This study identifies UFMylation of PDH as a regulator of mitochondrial metabolism, showing it enhances pyruvate oxidation and TCA cycle activity.

L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

Carbohydrate adaptation drives liver-brain axis maturation

The paper shows that LACTB2 in the liver regulates mitochondrial maturation to coordinate carbohydrate metabolism with brain development in mice.

An interactive web application for exploring human plasma and fibroblast metabolomics data from patients with inborn errors of metabolism

The paper introduces a web application for exploring metabolomics data from plasma and fibroblasts of patients with inborn errors of metabolism, enabling analysis of metabolic deviations and relationships.