Author

Varun Sondhi

Children's Medical CenterORCID 0000-0002-0253-7624Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Ralph J. DeBerardinisiD· 3 shared Feng CaiiD· 2 shared Ling CaiiD· 2 shared Phong T. NguyeniD· 2 shared Tamaratare OguiD· 2 shared Zheng WuiD· 2 shared Alexandros Zografakis· 1 shared Ana G. PedrosaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiochemistry

Ralph J. DeBerardinisORCID

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3 papers

Recent·Most cited

UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism

Phong Nguyen, Zheng Wu, Dohun Kim, Tamaratare Ogu, Siyu Yin, Varun Sondhi, Feng Cai, Trevor S. Tippetts, Annie Jen, Evgenia Shishkova, Ling Cai, Dennis Dumesnil, Margaret B. Cervantes, Hongli Chen, Prashant Mishra, , Ralph J. DeBerardinis

This study identifies UFMylation of PDH as a regulator of mitochondrial metabolism, showing it enhances pyruvate oxidation and TCA cycle activity.

bioRxiv · Mar 18, 2026 · PreprintBiochemistry

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

Zheng Wu, Phong T. Nguyen, Varun Sondhi, Run-Wen Yao, Zhifang Lu, Tao Dai, Jui‐Chung Chiang, Feng Cai, Imani M. Williams, Eliot B. Blatt, Zeng‐Fu Shang, Ling Cai, Jing Zhang, Mya D. Moore, Islam Alshamleh, , Ralph J. DeBerardinis

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

Science · Nov 6, 2025Peer-reviewedBiochemistry

PEX39 facilitates the peroxisomal import of PTS2 proteins

Walter W. Chen, Tony A. Rodrigues, Daniel Wendscheck, Ana G. Pedrosa, Chendong Yang, Tânia Francisco, Till Möcklinghoff, Alexandros Zografakis, Bernardo Nunes-Silva, Reut Ester Avraham, Ana Rita Silva, Maria J. Ferreira, Hirak Jyoti Das, Janet Koster, Simone Neuwirth, , Bettina Warscheid

This study identifies PEX39 as a cytosolic peroxin that facilitates PTS2-protein import by interacting with PEX7 and stabilizing its binding to cargo.

Nature Cell Biology · Jul 30, 2025Peer-reviewedCell Biology