Trevor S. Tippetts

The paper identifies LepR+ cells as a niche for thrombopoiesis by producing CXCL14, which regulates lipid metabolism and terminal differentiation in megakaryocytes.

This study shows that localized loss of G6pc1 in liver zones causes local glycogen accumulation but not systemic disease, highlighting organ-wide compensation for metabolic homeostasis.

The paper develops a platform to trace 30 nitrogen isotope-labeled metabolites, revealing cell state-specific pyrimidine synthesis pathway preferences in primitive and differentiated cells.

This study shows that mitoSAM-dependent lipoylation is essential for postnatal heart development by enabling metabolic remodeling from glycolysis to oxidative phosphorylation.

This study identifies UFMylation of PDH as a regulator of mitochondrial metabolism, showing it enhances pyruvate oxidation and TCA cycle activity.

This study shows that mitochondrial cardiolipin deficiency disrupts electron transport chain function, leading to oxidative stress and promoting MASH in mice and humans.