SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma
Emily A. Costa, Barbara Vaz de Mello, Corrin A. Wohlhieter, Subhiksha Nandakumar, Samuel Tischfield, Yingqian Ada Zhan, Harsha Sridhar, Dennis Kinyua, Elisa de Stanchina, Wenfei Kang, Ning Fan, Alister P. W. Funnell, John E. Lazar, Justin Jee, Irina Linkov, , Charles M. Rudin
The paper identifies SMARCA4/STK11/KEAP1 triple mutant lung adenocarcinoma as a poor prognosis subset and links it to TGF-β pathway activation.
Translational Oncology · Jul 20, 2026Peer-reviewedCancer Biology