Author

John E. Lazar

Altius Institute for Biomedical SciencesORCID 0000-0002-3142-1858Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Daniel BatesiD· 3 shared Alex P. ReynoldsiD· 2 shared Douglas Dunn· 2 shared Eric HaugeniD· 2 shared Eric RynesiD· 2 shared Fidencio Jun Neri· 2 shared Jessica M. Halow· 2 shared John A. StamatoyannopoulosiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Daniel BatesORCID

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Author profile →

3 papers

Recent·Most cited

SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma

Emily A. Costa, Barbara Vaz de Mello, Corrin A. Wohlhieter, Subhiksha Nandakumar, Samuel Tischfield, Yingqian Ada Zhan, Harsha Sridhar, Dennis Kinyua, Elisa de Stanchina, Wenfei Kang, Ning Fan, Alister P. W. Funnell, John E. Lazar, Justin Jee, Irina Linkov, , Charles M. Rudin

The paper identifies SMARCA4/STK11/KEAP1 triple mutant lung adenocarcinoma as a poor prognosis subset and links it to TGF-β pathway activation.

Translational Oncology · Jul 20, 2026Peer-reviewedCancer Biology

Global reference mapping and dynamics of human transcription factor footprints

Jeff D. Vierstra, John E. Lazar, Richard S. Sandstrom, Jessica M. Halow, Kristen Lee, Daniel Bates, Morgan Diegel, Douglas Dunn, Fidencio Jun Neri, Eric Haugen, Eric Rynes, Alex P. Reynolds, Jemma S. Nelson, Audra Johnson, Mark Frerker, , John A. Stamatoyannopoulos

The paper maps transcription factor footprints across 243 human cell and tissue types, revealing their structure, function, and relationship to genetic variation and disease.

Nature · Jul 29, 2020Peer-reviewedGenomics

Atlas and developmental dynamics of mouse DNase I hypersensitive sites

Charles E. Breeze, John E. Lazar, Tim R. Mercer, Jessica M. Halow, Ida W. Smoak, Kristen Lee, Sean Ibarrientos, Andrés Castillo, Fidencio Jun Neri, Eric Haugen, Eric Rynes, Alex P. Reynolds, Daniel Bates, Morgan Diegel, Douglas Dunn, , John A. Stamatoyannopoulos

The paper creates a mouse regulatory DNA atlas by mapping DNase I hypersensitive sites across development and shows dynamic changes in regulatory elements and transcription factor activity.

bioRxiv · Jun 26, 2020 · PreprintGenomics