Compromised striatal structure and function in mouse models of RARB-related disorder
Nicolas Zinter, Devanshi Shah, Victorine Artot, Nicolas Lemmetti, Hanna Semaan, Rodolphe Soret, Nicolas Pilon, Christina Nassif, Marie‐Christine Birling, Amrita Raja-Ravi-Shankar, Valérie Fraulob, Véronique Caron, André Tremblay, Gerardo A. Zapata, Marc Danik, , Wojciech Krężel
This study investigates RARB-RD mouse models and finds that both GOF and DN variants compromise striatal structure and function, with transcriptional effects more severe than a null allele.
Brain · Sep 17, 2026Peer-reviewedNeuroscience