Madhu Ramesh

AlphaGenome informed machine learning for pathogenicity prediction of germline mutations

AGVarPred is a gradient-boosted classifier that improves pathogenicity prediction of germline variants by integrating AlphaGenome features, outperforming existing models across SNVs and indels.

MiR-7a-Klf4 axis as a regulator and therapeutic target of neuroinflammation and ferroptosis in Alzheimer's disease

The paper identifies miR-7a-Klf4 as a regulator of neuroinflammation and ferroptosis in Alzheimer's disease and shows its therapeutic potential.

Asrij/OCIAD1 depletion reduces inflammatory microglial activation and ameliorates Aβ pathology in an Alzheimer's disease mouse model

This study shows that reducing Asrij levels in an Alzheimer's disease mouse model decreases microglial inflammation and Aβ pathology, improving cognitive and neuronal outcomes.

Naphthalene monoimide derivative ameliorates amyloid burden and cognitive decline in a transgenic mouse model of Alzheimer's disease

This study identifies TGR63, a naphthalene monoimide derivative, as a promising therapeutic for Alzheimer's disease by reducing amyloid burden and cognitive decline in a mouse model.