Nicolas Zinter

This study investigates RARB-RD mouse models and finds that both GOF and DN variants compromise striatal structure and function, with transcriptional effects more severe than a null allele.

The paper shows statins and mevalonate pathway inhibition increase STMN2 and ATF3, promoting neuronal regeneration in neurodegenerative disease.

This study shows that reduced RARβ signaling in HD mouse models accelerates motor and transcriptional abnormalities, suggesting a protective role for RARβ in disease progression.