Rac1 and CHK1 Converge on Abi-1 to Regulate DNA Repair Dependency and Treatment Response in Human Cancers
Yiheng Huang, Elizabeth C. McCulla, Jihan Park, Annabel Yang, Timothy Jho, Angelica Lin, Jie Xu, Kari Wilder-Romans, Luke D. Hess, Jing Li, Ningning Liang, Ziqing Zhu, Deven Kothari, Karen Jin, Sarah H. Kim, , Weihua Zhou
This study identifies Abi-1-S323 phosphorylation as a biomarker for DNA repair states and treatment response in cancers, showing its role in regulating radiosensitivity through Rac1 and CHK1 signaling.
bioRxiv · Sep 18, 2026 · PreprintCancer Biology