Comparative analysis of the Illumina Mouse Methylation BeadChip and Reduced Representation Bisulphite Sequencing for routine DNA methylation analysis of murine samples
Lochlan Fennell, Günter Härtel, Diane McKeone, Catherine Bond, Alexandra M. Kane, Barbara Leggett, Ann‐Marie Patch, Vicki Whitehall
The paper compares DNA methylation analysis using the Mouse Methylation BeadChip and reduced representation bisulphite sequencing in murine colorectal carcinogenesis models, showing similar differential methylation detection with different coverage efficiencies.
bioRxiv · Mar 7, 2022 · PreprintGenomics