Lochlan Fennell

This study compares Kras and Braf mutant intestinal neoplasia in mice, showing Kras mutations lead to less aggressive serrated lesions with reduced WNT signaling activation and attenuated DNA methylation changes compared to Braf mutations.

This paper creates a spatial atlas of colorectal cancer and normal colon, identifying nine niches and their gene expression profiles, and links stromal changes to tumour differentiation.

The paper compares DNA methylation analysis using the Mouse Methylation BeadChip and reduced representation bisulphite sequencing in murine colorectal carcinogenesis models, showing similar differential methylation detection with different coverage efficiencies.

The paper identifies five distinct subtypes of colorectal cancer using DNA methylation profiling and links them to specific mutations and gene body methylation patterns.