Genetic control couples TGFβ-independent pluripotent stem cell renewal to deterministic forward programming across germ layers
Sveva Bottini, Francesca Amodeo, Divyashree Avnoor, Mario De Gregorio, Maddalena Arigoni, Fabian Bachinger, Philip Barrett, David L. Mack, Paolo Ettore Porporato, Paola Defilippi, Ludovic Vallier, Alec S.T. Smith, Elisa Balmas, Alessandro Bertero
This paper introduces GERALT, a genetic circuit that enables TGFβ-independent hiPSC renewal and inducible lineage programming, improving differentiation efficiency and reducing medium complexity.
bioRxiv · Oct 27, 2026 · PreprintSynthetic Biology