Paolo Ettore Porporato

This paper introduces GERALT, a genetic circuit that enables TGFβ-independent hiPSC renewal and inducible lineage programming, improving differentiation efficiency and reducing medium complexity.

This study identifies TGS1 as a methyltransferase that modifies mRNAs encoding mitochondrial proteins in AML, promoting oxidative phosphorylation and cell survival, and shows its potential as a therapeutic target.

This paper identifies bedaquiline as a synergistic agent that enhances proteasome inhibitor efficacy and overcomes resistance in multiple myeloma and related B-cell malignancies.

This study shows that niacin replenishes NAD+ levels, improves mitochondrial function, and reduces cachexia in cancer models and patients.