Nuclear eNOS interacts with and S-nitrosates ADAR1 to modulate type I interferon signaling and endothelial function.
Xiaozhu Zhou, Carsten Tobias Kuenne, Stefan Günther, Ilka Wittig, Beyza Güven, Doha Boutguetait, Fredy Delgado Lagos, Nadja Sachs, Lars Mäegdefessel, Oliver Josef Müller, Christian Münch, Stefan Offermanns, Ingrid Fleming, Mauro Siragusa
This study identifies nuclear eNOS's role in modulating ADAR1 activity and type I interferon signaling, linking NO bioavailability to endothelial function and atherogenesis.
Circulation · Oct 29, 2025Peer-reviewedPhysiology