George Edward Allen

Molecular factors shaping small RNA content in mouse sperm

This study identifies molecular factors shaping small RNA content in mouse sperm, revealing dynamics and protein associations during spermiogenesis and capacitation.

Puf3 contributes to changes in mRNA solubility, translation elongation dynamics at rare arginine codons and loss of protein homeostasis in cells lacking Not4

Intrinsic features of the RNase E membrane targeting sequence specify RNA degradosome organisation and activity

This study investigates the role of the RNase E membrane targeting sequence in bacterial RNA degradosome organization and activity, showing its importance for foci morphology, virulence, and transcriptome regulation.

Critical functions and key interactions mediated by the RNase E scaffolding domain in Pseudomonas aeruginosa

This study identifies key interactions and functions of the RNase E CTD in Pseudomonas aeruginosa, revealing its role in transcript regulation, virulence, and environmental adaptation.

Cytosolic N6AMT1-dependent translation supports mitochondrial RNA processing

The paper identifies N6AMT1's role in cytosolic translation of mitochondrial RNAse P subunits, showing its necessity for mitochondrial RNA processing and function.

Intrinsically disordered regions regulate RhlE RNA helicase functions in bacteria

The paper shows that intrinsically disordered regions (IDRs) in RhlE RNA helicases regulate their functional specificity and subcellular localization in Pseudomonas aeruginosa.

Not4-dependent targeting of MMF1 mRNA to mitochondria limits its expression via ribosome pausing, Egd1 ubiquitination, Caf130, No-Go-Decay and autophagy

The paper identifies a mechanism called Mito-ENCay that limits MMF1 mRNA expression by targeting it to mitochondria and triggering quality control processes.

Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events

The paper shows that Not1 and Not4 oppositely regulate mRNA solubility, affecting co-translational dynamics in yeast.

eIF4E3 Forms an Active eIF4F Complex during Stresses (eIF4FS) Targeting mTOR and Re-Programs the Translatome.

The paper identifies eIF4E3's role in forming an active eIF4F complex under stress, reprogramming the translatome through specific mRNA selection.

Switch from translation initiation to elongation needs Not4 and Not5 collaboration

The paper shows Not4 and Not5 regulate translation initiation and elongation differently, affecting codon-dependent ribosome behavior and translation efficiency.