Mauro Siragusa

This paper identifies immunomodulatory endothelial cells (IMEC) that present antigens on MHC class II and activate T cells in atherosclerosis.

This study identifies SMOC1 as a regulator of EndMT in cardiac repair, showing its role in modulating TGF-β/endoglin signaling and preventing pathological fibrosis after MI.

This study identifies miP-PSTPIP2, an inflammation-induced microprotein that modulates endothelial cell endocytosis, cytoskeleton dynamics, and barrier function by affecting Arp2/3-mediated actin dynamics.

This study identifies nuclear eNOS's role in modulating ADAR1 activity and type I interferon signaling, linking NO bioavailability to endothelial function and atherogenesis.

The paper expands and refines a reference catalog of human non-canonical open reading frames (ncORFs) by incorporating more datasets and introducing a translation signature score framework to prioritize high-quality ncORFs.