Author

Timothy I. M. Tree

King's College LondonORCID 0000-0002-6973-5377Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Alexandra Howell· 1 shared Andrew Kelvin SewelliD· 1 shared Andrew Tym HattersleyiD· 1 shared Anton Lindqvist· 1 shared Clara Domingo‐VilaiD· 1 shared Colin Mark DayaniD· 1 shared Danijela TatovićiD· 1 shared David Cameron WraithiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperImmunology

Alexandra Howell

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tracking GAD-specific T-cell expansions in Type 1 diabetes by intradermal GAD-Alum challenge

Stephanie Jean Hanna, Emma Robinson, Terri C. Thayer, Maki Nakayama, Laurie G. Landry, Robert Andrews, Garry M. Dolton, Joanne E. Davies, Evangelia Williams, James Alexander Pearson, Andrew Kelvin Sewell, Parth Narendran, David Cameron Wraith, Alexandra Howell, Philippa Young, , Danijela Tatović

This paper uses intradermal GAD-Alum challenge and scRNA-seq to identify and profile GAD-reactive T cells in type 1 diabetes.

JCI Insight · May 22, 2026Peer-reviewedImmunology

The minor spliceosome is a master immune regulator

MB Johnson, James Russ‐Silsby, Paul A. Blair, Molly Govier, Georgia Bonfield, Clara Domingo‐Vila, Matthew Neil Wakeling, Richard A. Oram, Sarah Elizabeth Flanagan, Timothy I. M. Tree, Kashyap Amratlal Patel, Andrew Tym Hattersley, Elisa De Franco

The paper identifies biallelic variants in RNU6ATAC and RNU4ATAC as causes of early-onset autoimmune diabetes and immune dysregulation, showing the minor spliceosome's role in immune regulation.

medRxiv · Sep 12, 2025 · PreprintGenetic & Genomic Medicine

Low-dose IL-2 reduces IL-21+ T cells and induces a long-lived anti-inflammatory gene expression signature inversely modulated in COVID-19 patients

Jiayuan Zhang, Fiona Hamey, Dominik Trzupek, Marius Mickunas, Mercede Lee, Leila Godfrey, Jennie H. M. Yang, Marcin Ł. Pękalski, Jane Kennet, Frank Waldron-Lynch, Mark L. Evans, Timothy I. M. Tree, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira

medRxiv · Apr 5, 2022 · PreprintGenetic & Genomic Medicine