Mitochondria drive microglial NRLP3 inflammasome activation via TSPO
Aarti Singh, Manuel Rigon, Tong Guo, Danilo Faccenda, Gopinath Lakshmanan, Dong Xia, Marta Gramaça Caldeira, Jordi Lopez-Tremoleda, Z. Falah Hassan Al-Khateeb, Rosella Abeti, Paola Giunti, Michelangelo Campanella
This study shows TSPO on mitochondria promotes microglial inflammasome activation by stabilizing NLR proteins, inhibiting mitophagy, and enhancing pro-inflammatory gene expression, leading to excitotoxicity.
Pharmacological Research · Feb 19, 2026Peer-reviewedCell Biology