An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants
Bruce Nmezi, Guillermo Rodríguez Bey, Talia DeFrancesco Oranburg, Kseniia Dudnyk, Santana M. Lardo, Nathan Herdman, Anastasia M. Jacko, Sandy Rubio, Emanuel Loeza‐Alcocer, Julia Kofler, Dongkyeong Kim, Julia Rankin, Emma C. Kivuva, Nicholas J. Gutowski, Katherine R. Schon, , Quasar Saleem Padiath
The paper identifies a silencer element lost in ADLD patients that specifically targets oligodendrocyte overexpression of LMNB1, linking it to disease pathogenesis.
Nature Communications · Feb 5, 2025Peer-reviewedGenetics