Julia Kofler

The paper analyzes somatic mutations in neurons from FTLD-TDP type C patients and controls, finding extensive low-frequency variants in TARDBP and other genes.

This paper develops a deep learning framework to segment and quantify cerebral amyloid angiopathy in whole-slide histopathology images, achieving high accuracy and robust generalization across cohorts.

This paper introduces a stereotaxic container for human brain fixation that enables precise MRI-to-histology alignment during postmortem studies.

This study identifies a shared proteomic profile in Alzheimer's disease with and without psychosis and a separate molecular signature linked to postsynaptic density disruption.

This study identifies nuclear BIN1 isoforms in oligodendrocytes and shows their role in regulating c-Myc-mediated cell cycle control, linking BIN1 dysregulation to myelin pathology in Alzheimer's disease.

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

The paper identifies a silencer element lost in ADLD patients that specifically targets oligodendrocyte overexpression of LMNB1, linking it to disease pathogenesis.

This study confirms the expression of 3R and 4R Tau isoforms and phosphorylation sites in marmoset brains, supporting their use as a model for Alzheimer's disease.

This study identifies differentially expressed genes and pathways in Alzheimer's disease brain tissue from African American donors, highlighting potential targets for treatment.

The paper isolates and analyzes amyloid fibrils from AD brains and models to identify proteins associated with fibril formation and toxicity, finding new proteins and validating their roles.

This study identifies JADE1 as a novel genetic factor in tauopathy through genome-wide association and functional validation in human and Drosophila models.