eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma
Alejandro Schcolnik‐Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad, Zaynab Nouhi, Sarah St-Amand, Caroline Capdevielle, Donia Issa, Mélody Riaud, April A. N. Rose, Mireille Khacho, Frédérick A. Mallette, Martín Roffé, Tommy Alain, Ivan Topisirović, Laura Hulea
This study shows eIF4A inhibition disrupts resistance mechanisms in BRAF-mutant melanoma by targeting translational and metabolic programs, improving tumor control when combined with BRAF inhibitors.
bioRxiv · Sep 8, 2026 · PreprintCancer Biology