Mireille Khacho

This study shows eIF4A inhibition disrupts resistance mechanisms in BRAF-mutant melanoma by targeting translational and metabolic programs, improving tumor control when combined with BRAF inhibitors.

This study shows PARKIN is essential for coordinating mitochondrial and nuclear processes in muscle stem cells during regeneration, with loss of PARKIN causing metabolic and RNA processing defects.

This study shows that internally produced polyP in human cells activates signaling pathways and alters gene and protein expression through ectopic expression of a bacterial polyP synthetase.