Author

Tommy Alain

University of OttawaORCID 0000-0002-0396-9138Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:metagenomics· 1

Frequent Co-Authors

Alejandro Schcolnik‐CabreraiD· 1 shared Anavasadat Sadr Hashemi NejadiD· 1 shared April A. N. RoseiD· 1 shared Caroline CapdevielleiD· 1 shared Christos G. GkogkasiD· 1 shared Donia Issa· 1 shared Frédérick A. MalletteiD· 1 shared Huy‐Dung HoangiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Alejandro Schcolnik‐CabreraORCID

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2 papers

Recent·Most cited

eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma

Alejandro Schcolnik‐Cabrera, Meriem Takdenti, Anavasadat Sadr Hashemi Nejad, Zaynab Nouhi, Sarah St-Amand, Caroline Capdevielle, Donia Issa, Mélody Riaud, April A. N. Rose, Mireille Khacho, Frédérick A. Mallette, Martín Roffé, Tommy Alain, Ivan Topisirović, Laura Hulea

This study shows eIF4A inhibition disrupts resistance mechanisms in BRAF-mutant melanoma by targeting translational and metabolic programs, improving tumor control when combined with BRAF inhibitors.

bioRxiv · Sep 8, 2026 · PreprintCancer Biology

Induction of an alternative 5’ leader enhances translation of Inpp5e and resistance to oncolytic virus infection

Huy‐Dung Hoang, Tyson Ernst Graber, Jianjun Jia, Nasana Vaidya, Victoria Heather Gilchrist, Xiao Xiang, Wencheng Li, Kyle Northcote Cowan, Christos G. Gkogkas, Maritza Jaramillo, Seyed Mehdi Jafarnejad, Tommy Alain

The paper identifies an alternative 5' leader in Inpp5e mRNA that enhances translation and confers resistance to oncolytic virus infection in cancer cells.

Cell Reports · Dec 1, 2019Peer-reviewedMolecular Biology