Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL
Yuxuan Liu, Haowen Jiang, Jingjing Liu, Lucille Stuani, Milton J. Merchant, Astraea Jager, Abhishek Koladiya, Ti‐Cheng Chang, Pablo Domizi, Jolanda Sarno, Timothy Keyes, Dorra Jedoui, Ao Wang, Jodie Meng, Felix J. Hartmann, , Kara Lynn Davis
This study identifies uridine metabolism as a therapeutic target for chemo-resistant B-ALL by linking active signaling to uridine dependency and demonstrating DHODH inhibition as a promising treatment.
bioRxiv · Jan 27, 2025 · PreprintCancer Biology