Abhishek Koladiya

Trp53 heterozygosity defines novel states impacting tumor plasticity and progression in Kras-initiated non-small cell lung cancer

This study shows that TP53 heterozygosity in Kras-mutant lung cancer affects tumor plasticity and progression, with distinct genomic and survival outcomes compared to complete TP53 loss.

CellFuse Enables Multi-modal Integration of Single-cell and Spatial Proteomics Data

CellFuse integrates single-cell and spatial proteomics data using a deep learning framework, outperforming existing methods in accuracy and efficiency.

Single-cell profiling of CAR-T CD19 cell phenotypes and immune system dynamics in pediatric BCP-ALL

This study characterizes CAR+ T-cell subsets and immune system dynamics in pediatric BCP-ALL patients treated with tisagenlecleucel, finding correlations between immune cell changes and cytokine release syndrome.

Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL

This study identifies uridine metabolism as a therapeutic target for chemo-resistant B-ALL by linking active signaling to uridine dependency and demonstrating DHODH inhibition as a promising treatment.

SOM-based embedding improves efficiency of high-dimensional cytometry data analysis

EmbedSOM improves high-dimensional cytometry data analysis by providing efficient, scalable visualization of cell populations and transitions without downsampling.