Felix J. Hartmann

UELer: a Jupyter-based framework for interactive exploration of multiplexed imaging datasets

UELer enables interactive exploration of multiplexed imaging datasets within Jupyter notebooks by linking image views with analysis results without requiring additional infrastructure.

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

This study shows that loss of the Y chromosome in lung adenocarcinoma causes epigenetic and transcriptomic changes that increase lineage plasticity and poor clinical outcomes.

Cell-of-Origin, not Oncogenic Effect, Determines esmoplastic Immune Exclusion in KRAS-Driven Liver Cancer

This study shows that the cell-of-origin, not oncogenic pathway activation, determines the desmoplastic immune-excluded tumor microenvironment in KRAS-driven liver cancer.

Learning tissue representation by identification of persistent local patterns in spatial omics data

The paper introduces Kasumi, a method to identify persistent local patterns in spatial omics data for improved patient stratification in cancer.

Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL

This study identifies uridine metabolism as a therapeutic target for chemo-resistant B-ALL by linking active signaling to uridine dependency and demonstrating DHODH inhibition as a promising treatment.

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition

The paper uses spatial imaging and computational analysis to identify features in metastatic tumors that predict response to immune checkpoint inhibition in TNBC patients.

Supervised dimensionality reduction for exploration of single-cell data by Hybrid Subset Selection - Linear Discriminant Analysis

This paper introduces a supervised dimensionality reduction method using hybrid subset selection with linear discriminant analysis to improve visualization and analysis of single-cell data.