Douglas Colby

Direct recruitment of RNA Polymerase II by NANOG to activated target genes

This study identifies a direct interaction between NANOG and RNA Polymerase II that regulates transcription and ESC self-renewal.

TET knockout cells transit between pluripotent states and exhibit precocious germline entry

This study shows that TET protein deficiency in mouse ESCs leads to impaired somatic differentiation and accelerated germline entry.