Chemical suppression of a bacterial immune system revives repressed phages
Chengqian Zhang, Dziugas Sabonis, Yanyao Cai, Zhiyu Zang, Giedrė Tamulaitienė, Joseph P. Gerdt
The paper identifies small molecule inhibitors of the Thoeris antiphage immune system in bacteria, showing that persistent immunity is required to prevent phage revival and population collapse.
bioRxiv · Apr 28, 2026 · PreprintBiochemistry