Shuai Le

The paper introduces contactMAP, a photocatalytic crosslinking method for high-resolution mapping of protein neighborhoods, showing it rivals or outperforms existing photo-PLP methods.

The paper shows Pseudomonas aeruginosa uses a CRISPR-Cas system to silence a proline-codon toxin that stops phage growth, revealing a defense mechanism against anti-CRISPR phages.

The paper shows RNA phages are eliminated in dormant bacteria via ROS-mediated damage, but survival depends on genomic redundancy through co-infection.

This study identifies chemical inhibitors that block a bacterial immune system, enhancing phage therapy efficacy against resistant strains.

This study identifies Dap2, a phage protein that inhibits bacterial type III secretion system and synergizes with Dap1 to protect phage-encoded HNH endonuclease from degradation.