Giedrė Tamulaitienė

Csx15 is a broad specificity ring nuclease bridging CRISPR-Cas and CBASS cyclic nucleotide signaling systems

This study identifies Csx15 as a ring nuclease that degrades cyclic nucleotides from both CRISPR-Cas and CBASS systems, revealing its role in regulating signaling pathways.

Chemical suppression of a bacterial immune system revives repressed phages

The paper identifies small molecule inhibitors of the Thoeris antiphage immune system in bacteria, showing that persistent immunity is required to prevent phage revival and population collapse.

Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation

This study reveals the structure of the type II-A CRISPR-Cas prespacer selection supercomplex and elucidates the role of Csn2 in Cas9-mediated spacer acquisition.

Chemical inhibition of a bacterial immune system

This study identifies chemical inhibitors that block a bacterial immune system, enhancing phage therapy efficacy against resistant strains.

Deoxydinucleotides activate the bacterial anti-phage defense system ApeA

The paper shows that deoxydinucleotides activate the bacterial anti-phage defense system ApeA by binding to a conserved pocket, enabling broad protection against phage infection.

Filament formation activates protease and ring nuclease activities of CRISPR SAVED-Lon

The paper characterizes the CRISPR SAVED-Lon system, showing that filament formation activates protease and ring nuclease activities, leading to growth arrest in E. coli.