FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver
H. Wang, C. Nikain, J. Amengual, M. La Forest, Y. Yu, M. C. Wang, R. Watts, R. Lehner, Y. Qiu, M. Cai, I. J. Kurland, I. J. Goldberg, S. Rajan, M. M. Hussain, J. L. Brodsky, E. A. Fisher
This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.
bioRxiv · Dec 5, 2023 · PreprintBiochemistry