Author

J. L. Brodsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

H. E. Vorndran· 2 shared L. M. Hendershot· 2 shared A. Iyer· 1 shared A. L. Marciszyn· 1 shared A. Porter· 1 shared A. R. Flory· 1 shared A. R. Subramanya· 1 shared C. J. Guerriero· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

H. E. Vorndran

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum functions

M. J. Mann, C. Melendez-Suchi, M. Sukhoplyasova, A. R. Flory, M. Carson Irvine, A. Iyer, H. E. Vorndran, C. J. Guerriero, J. L. Brodsky, L. M. Hendershot, T. Buck

This study shows that loss of Grp170 causes ER dysfunction, including BiP misregulation and UPR activation, leading to cell death in mouse embryonic fibroblasts.

Molecular Biology of the Cell · Apr 1, 2024Peer-reviewedCell Biology

Excess dietary sodium partially restores salt and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron

A. Porter, H. E. Vorndran, A. L. Marciszyn, S. M. Mutchler, A. R. Subramanya, T. R. Kleyman, L. M. Hendershot, J. L. Brodsky, T. M. Buck

This study shows that excess dietary sodium partially restores electrolyte imbalance and kidney injury markers in GRP170-deficient mice but not weight or tubule integrity.

bioRxiv · Jan 13, 2024 · PreprintCell Biology

Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins

E. Chuang, R. R. Cupo, J. R. Bevan, M. L. Rice, S. Mao, E. L. Gorenberg, K. L. Mack, D. M. Huryn, P. Wipf, J. L. Brodsky, J. Shorter

The paper identifies a small-molecule stimulator of the human Hsp70-disaggregase system that selectively activates DnaJB1- or DnaJB4-containing chaperone complexes.

bioRxiv · Jan 11, 2024 · PreprintBiochemistry

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

H. Wang, C. Nikain, J. Amengual, M. La Forest, Y. Yu, M. C. Wang, R. Watts, R. Lehner, Y. Qiu, M. Cai, I. J. Kurland, I. J. Goldberg, S. Rajan, M. M. Hussain, J. L. Brodsky, E. A. Fisher

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

bioRxiv · Dec 5, 2023 · PreprintBiochemistry