I. J. Kurland

FITM2 deficiency results in ER lipid accumulation, ER stress, reduced apolipoprotein B lipidation, and VLDL triglyceride secretion in vitro and in mouse liver

This study shows FITM2 deficiency reduces VLDL triglyceride secretion and causes ER stress and lipid accumulation in liver cells and mice.

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea

This study identifies Cyb5r3 downregulation as a mechanism of sulfonylurea failure and shows that a Cyb5r3 activator can reverse this failure in an animal model.

Neuronal glucose metabolism sets cholinergic tone and controls thermo-regulated signaling at the neuromuscular junction

This study shows that increasing glycolysis in cholinergic neurons boosts acetylcholine levels, reduces blood pressure and heart rate, and improves cold resistance.

Glutamine is required for M1-like polarization in response to Mycobacterium tuberculosis infection

This study identifies glutamine as essential for M1-like macrophage polarization during Mycobacterium tuberculosis infection through metabolic reprogramming involving the TCA cycle and biosynthesis of signaling molecules and antimicrobial metabolites.

Radiation Exposure of the Base of the Heart Accelerates Coronary Atherosclerosis

This study shows that radiation to the base of the heart accelerates coronary atherosclerosis in mice, while apex irradiation does not, suggesting targeted protection of the heart base may reduce radiation-induced atherosclerosis in patients.