Author

B. Ghetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. G. Murzin· 2 shared M. Goedert· 2 shared A. Aubert· 1 shared A. Possenti· 1 shared A. Srivastava· 1 shared B. Caughey· 1 shared B. Falcon· 1 shared C. Franco· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

A. G. Murzin

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3 papers

Recent·Most cited

Tau filaments with the Alzheimer fold in cases with MAPT mutations V337M and R406W

C. Qi, S. Lovestam, A. G. Murzin, S. Peak-Chew, C. Franco, M. Bogdani, C. Latimer, J. R. Murrell, P. W. Cullinane, Z. Jaunmuktane, T. D. Bird, B. Ghetti, S. H. W. Scheres, M. Goedert

The paper determines the structures of tau filaments in individuals with MAPT mutations V337M and R406W using cryo-EM, finding the Alzheimer fold in all cases and a new triple filament assembly.

bioRxiv · Apr 29, 2024 · PreprintBiophysics

Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning

R. I. Horne, E. Andrzejewska, P. Alam, Z. F. Brotzakis, A. Srivastava, A. Aubert, M. Nowinska, R. C. Gregory, R. Staats, A. Possenti, S. Chia, P. Sormanni, B. Ghetti, B. Caughey, T. P. J. Knowles, M. Vendruscolo

This paper uses structure-based machine learning to identify potent small molecule inhibitors of α-synuclein aggregation, achieving compounds two orders of magnitude more potent than previous reports.

bioRxiv · Nov 10, 2021Biophysics

Structures of filaments from Pick’s disease reveal a novel tau protein fold

B. Falcon, W. Zhang, A. G. Murzin, G. Murshudov, H. J. Garringer, R. Vidal, R. A. Crowther, B. Ghetti, S. Scheres, M. Goedert

This paper determines the structure of tau filaments from Pick’s disease using cryo-EM, revealing a novel tau protein fold distinct from Alzheimer's disease filaments.

bioRxiv · Apr 16, 2018Biophysics