Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations
A. Subramaniam, C. Sanden, L. Moura-Castro, K. Zemaitis, L. Schmiderer, A. Backstrom, E. Arvidsson, S. Hultmark, N. Miharada, K. Paulsson, T. Fioretos, J. Larsson
This study demonstrates that partial STAG1 perturbation selectively kills STAG2-mutated AML cells while sparing normal HSCs, showing synthetic lethality in xenograft models.
bioRxiv · Feb 18, 2022Cancer Biology